Chip blacklist. 9% overlap with a Blacklist-generated exclusion set, identical performance on ChIP-seq quality metrics but a smaller genome footprint (Klasfeld and. Chip blacklist

 
9% overlap with a Blacklist-generated exclusion set, identical performance on ChIP-seq quality metrics but a smaller genome footprint (Klasfeld andChip blacklist Citing concerns over national security, Semiconductor Manufacturing International Corporation — China’s single largest chip maker — has now effectively been blacklisted from buying

5 billion ($6. And if you do it, sort the bam and make sure the chromosome names are ordered using the same tool between blacklist bed and your bams. Drosophia melanogaster experiments. No existe un método seguro, confiable, legal ¡MUCHO MENOS GRATIS!{"payload":{"allShortcutsEnabled":false,"fileTree":{"docs":{"items":[{"name":"build_genome_database. . 10. Enables autoplay mode and Chip will continuously add recommended tracks to the queue. To improve signal-to-noise ratio, ChIP-Seq pipelines often remove data points that map to blacklist regions. md","contentType":"file. The US government has implemented wide-ranging prohibitions on using, buying, and selling video surveillance products including Dahua, Hikvision, and Huawei (Hisilicon) based products. Perform a Supplier Blacklist search for more reviews on Online Chip. 2. The US government has landed a fresh blow on China’s semiconductor ambitions by putting the country’s most advanced AI chip firms and its top memory chip maker on a trade blacklist, analysts say. ChIP-seq_SRR5179211_Rep1. S. S. The Biden administration is set to put chipmaker Yangtze Memory Technologies on a trade blacklist, in the latest US effort to target Chinese technology. Sort BAM files by genomic coordinates. For instance, Apple's new laptop will contain chips from industry leader Taiwan Semiconductor Manufacturing Company measuring 3 nanometres. Domain Creation Date. bam. To avoid blacklist emails, MailChimp leads a precise anti-denylist policy. Read on for details on how to work with the Office of Information Assurance to discontinue use of products from banned manufacturers. ChIP-Seq blacklists contain genomic regions that frequently produce artifacts and noise in ChIP-Seq experiments. Taiwan Semiconductor Manufacturing, or TSMC, is forecast to report net profit of T$192. By Reuters. Reading in peaksets: The first step is to read in a set of peaksets and associated metadata. NAND flash chips were originally single-layer, but in order to achieve higher storage capacity, several chips were stacked in the same package. The U. S. let ThreatIntelFeed = externaldata(DestIP: string)[@"with (format="txt", ignoreFirstRecord=True); let. YMTC, long in the crosshairs of the U. Example. That actually did a pretty impressive job of tying things up. /bassboost [percentage] Clear. 71. When I merged all of them (the ones from chr16 you. On Thursday, the Biden administration placed Phytium and six other Chinese firms and labs involved in high-performance computing on an export blacklist, blocking technology of American origin from. S. Description. 3 billion) in the three months to March, a 5% decrease from the same period a year earlier. iPhone model. -1. The enzyme-based CUT&RUN method overcomes. 31 6. --region (-r): 用于限制运行的基因组. May 23, 2023, at 2:52 p. The overlapped peaks of these two datasets crossing all tissues were defined as the zebrafish genome blacklist, and these regions were filtered out for all. S. blacklist will override that is defined in chip. • Twenty-one entities are major artificial intelligence (AI) chip research and development (R&D), manufacturing, and sales entities that are or have close ties to government organizations that support the PRC military and defense industry. bed. If both a TSV file and individual parameters are defined, then individual parameters will override those defined in a TSV file. 1. blacklist of the Chinese firm. Exclusive-US Lawmaker Demands Action Against Chinese Chip Firm CXMT After Micron. S. Note however i ran out of ram for bam > 8GB using bedtools intersect to filter. 3: Raspi blacklist. The command we use this time is samtools sort with the parameter -o. Blacklists for a range of species is available from. {"lab": {"correspondence": [{"contact_email": "cGV0ZXJfcGFya0BobXMuaGFydmFyZC5lZHU=", "@id": "/users/fb287a31-e765-41c5-8c1d-665f8e9f025b/", "display_title": "Peter. The Biden administration on Thursday added Chinese memory chipmaker YMTC and 21 "major" Chinese players in the artificial intelligence chip industry to a trade. The X9 is fitted with a Qualcomm Snapdragon 685 chip, with a relatively modest 4GB of RAM. While some of these blacklist removal service providers offer refunds if they are unable to unblock your iPhone, a good number of them are fraudulent and could steal your data. The peak call was using macs2. The National Defense Authorization Act (NDAA) prohibits the use of equipment manufactured by a limited set of Chinese manufacturers. Following the US’s recent blacklist of Huawei,. 3. Threat Profile. There is one more method which can be used to unblacklist iphone or any android phones. #3 Replace the IMEI Chip of the Blacklisted iPhone. (Bloomberg) -- The Biden administration plans to put Yangtze Memory Technologies and more than 30 other Chinese companies on a trade blacklist that would prevent them from buying certain American components, deepening tensions between the world’s two. President Joe Biden 's administration has taken the assault on China's chip. ChIP-seq allows researchers to study the landscape of chromatin modifications or. The U. genome. --version: 显示程序版本号并退出。. investments in the smartphone maker. The US government on Thursday added three dozen Chinese firms to its export blacklist, including the country’s top flash memory chip maker, marking Washington’s latest effort to block China. agencies talked about a proposal to toughen sales to SMIC and other chipmakers in China, the sources said. # RPKM (per bin) = number of reads per bin / (number of mapped reads (in millions) * bin length (kb)). S. curbs on the Chinese telecom company’s ability to obtain. S. government’s economic blacklist, the sources said, raising the total to 152 affiliates since Huawei was first added. And if you do it, sort the bam and make sure the chromosome names are ordered using the same tool between blacklist bed and your bams. export blacklist, including one of the country’s largest chipmakers, follows the Commerce Department’s crackdown in October on the. May 23, 2023, at 2:52 p. These twenty-eight entities have been determined by the U. ENCSR636HFF. Below are ten facts about Raymond Reddington, in no particular order. Blacklist error: Error: Invalid normalization Unable to apply Blacklist/Greylist. Our Top 10 Blacklist Raymond Reddington Facts. . Government to be acting contrary to the. S. /bassboost [percentage] Clear. QUATTRO. S. Changes the bassboost settings on the player. Blacklist regions account for a significant portion of ChIP-seq reads, are driven by artifacts in genome assemblies, and removal of these regions is essential to. S. 24/100. . Mereka juga dilarang mengakses teknologi penting asal AS, sehingga menghalangi kemampuan Huawei untuk merancang chip. Dale McGarrigle at June 17, 2021 12:48 am. For a more facile and versatile approach to artifactual signal removal, they employed MACS2 to call “peaks” in the input control samples using the entire Arabidopsis genome as. com Ethan Zhou = Ethan@part-Stock. Very little has changed in the way ChIP is most generally performed since it was first described 35 years ago, and remains fraught with signal-to-noise issues and artifacts. , 2007 ) and excellent positive and negative control loci are known ( Figure 3 ). Memory chipmaker Yangtze Memory Technologies (YMTC) was also put on the list, because of fears it could divert American technology to Chinese tech giants Huawei. S. 默认值是0。. Just visit either of the websites above and enter your IMEI (International Mobile Equipment Identity) to check the status of your phone. 31 6. Qualcomm, the American chip giant, is another customer of SMIC’s. -origin items in support of the China's military modernization efforts. Replace the IMEI Chip. S. The Blacklist bosses and star Megan Boone look back at Elizabeth Keen's most defining moments. We used this service to unlock a blacklisted iPhone 6 successfully from AT&T. The -1 option indicates. Original file name /Users/bonita/Desktop/Blacklist/GRCh38_unified_blacklist. S. Are you tired of being stuck with a blacklisted phone that you can't use on any network? Are you sick of trying to find a solution that actually works? Look. 0 (Poor) Domain Blacklist Status. reversed a ban on U. The US has blacklisted seven Chinese groups it accuses of building supercomputers to help its military. 3:03. bed > filtered_peaks. The listing means that companies. YMTC, long in the crosshairs of the U. One of the company’s latest NAND chip products, according to Chinese media reports, is a 232-layer chip that puts the firm on par with, if not better than, the world’s leading memory chip. By Stephen Nellis and Karen Freifeld. S. Chromatin immunoprecipitation coupled with high-throughput DNA sequencing (ChIP-Seq) is a powerful technology to profile the location of proteins of interest on a whole-genome scale. We all know that chip is still super lit even though they’re in Latvia. The Department of Commerce’s Bureau of Industry and Security (BIS) added 34 entities to the Entity List for their involvement in, or risk of becoming involved in, activities contrary to the foreign policy and national security interests of the United States. The ENCODE project uses Reference Genomes from NCBI or UCSC to provide a consistent framework for mapping high-throughput sequencing data. Then, in 2013, Samsung introduced the first 3D NAND, which had 24 layers of storage cells on one chip. S. S. 3 billion in sales in China, roughly 11 percent of its annual $30. Reddington had no access, no way to contact her, and couldn't find her. 2B). There are ways to manually change the IMEI of a phone if you have the phone in your possession. gzHowever, you can also individally define each file/parameter instead of a TSV file. genomicwindows,orallthepromoterregions inagenome). government effectively blocking. The DAC Exclusion List Regions (previously named "DAC Blacklisted Regions") aim to identify a comprehensive set of regions in the human genome that have anomalous, unstructured, high signal/read counts in next gen sequencing experiments independent of cell line and type of experiment. Although ChIP-seq is a relatively simple and robust protocol it does have limitations. It was. Seller Address: Joop Geesinkweg, Amsterdam 701 1114 AB, Netherlands. . The Department of Commerce statement noted. It first aired on September 23, 2013 on NBC. [2] The series was created by Jon Bokenkamp, and continues to be produced by Davis Entertainment, Universal Television and Sony Pictures Television, and executive produced by. However, none of the commonly used peak calling programs could. In this article we describe PeakPass, an efficient method to generate blacklists, and demonstrate that blacklists can increase ChIP-Seq data quality. All devices supported. The method is to replace your IMEI chip in your device. 85 0. com Ben Yeung = [email protected] Commerce Department’s Bureau of Industry and Security (BIS) has released a final rule adding four foreign companies to the Entity List for engaging in activities that are contrary to the national security or foreign policy interests of the United States. -based Micron Technology Inc, the chair of the U. To improve signal-to-noise ratio, ChIP-Seq pipelines often. This clause has caused significant concern due to fears that it will blacklist every Hikvision, Dahua, and Huawei HiSilicon chip user from selling to the US. S. The Biden administration plans to put Yangtze Memory Technologies and more than 30 other Chinese companies on a trade blacklist that would prevent. The Trump administration is considering whether to add China's top chipmaker SMIC to a trade blacklist, a Defense Department official said on Friday, as the United States escalates its crackdown. If the phone you wanted to unlock isn’t an iPhone, check out the second option. 5Example: How to apply a greylist. WASHINGTON — China's largest chipmaker and national offshore oil and gas producer were added Thursday to a blacklist of alleged Chinese military companies, the Pentagon said in an evening statement. So if you notice that important fusions are removed by the blacklist, please let me know. Original file name /Users/bonita/Desktop/Blacklist/GRCh38_unified_blacklist. China’s top flash memory chip maker Yangtze Memory Technologies Co (YMTC) could see its production hindered and technological progress capped if added to a US trade blacklist,. WASHINGTON, Dec 15 (Reuters) - The Biden administration on Thursday added Chinese memory chipmaker YMTC and 21 "major" Chinese players in the artificial intelligence chip sector to a trade. md","contentType":"file. S. The relevant thresholds include: logic chips of 16-nanometre, 14nm, or below; dynamic random access memory chips of 18nm half-pitch or less; and NAND flash memory chips with 128 layers or more. The output we requested from the Bowtie2 aligner is an unsorted SAM file, also known as Sequence Alignment Map format. 29 6. government, was added to the list over. The US and China continue to consciously uncouple. To defend against malicious packet attacks, the device uses ACLs to add users with the specific characteristic into a blacklist and discards the packets from the users in the blacklist. Texas, USA , Chips Find is a world-class distributor of electronic components. S. The 21 Chinese AI chip entities being added to the trade blacklist, which include Cambricon Technologies Corp 688256. By contrast, TSMC and other global competitors can etch circuits just three nanometers. Once you've requested your unlocking through doctorSIM, you will receive simple step-by-step instructions on how to unlock your iPhone. Figure S7 Significant peaks found in LFY and FD ChIP that overlap blacklist regions but are not masked by the greenscreen pipeline. government effectively blocking. 2. Huawei was added to a blacklist in May 2019 by the US Commerce Department over national security concerns. Not detected by any blacklist engine. 2 How to call ChIP-seq peaks using MACS2 You are provided with ChIP-seq BAM files in replicate. bam. deepT. DBA_BLACKLIST_GRCH37: Homo sapiens 37 (chromosomes are numbers) DBA_BLACKLIST_GRCH38: Homo sapiens 38 (chromosomes are numbers) DBA_BLACKLIST_MM9: Mus musculus 9 DBA_BLACKLIST_MM10: Mus musculus 10 DBA_BLACKLIST_CE10: C. reversed a ban on U. genome download data bioinformatics ucsc ensembl. . Tue 20 Dec 2022 // 20:30 UTC. In this paper we describe PeakPass, an. A precise set of rules is distributed over any user who wants to cooperate with the service. The 21 Chinese AI chip entities being added to the trade blacklist, which include Cambricon Technologies Corp. DiffBind: Differential binding analysis of ChIP-Seq peak data 1. ac. The Biden administration added 36 Chinese firms to its export blacklist on Thursday, doubling down on efforts to block Beijing’s access to advanced military and surveillance technology from the U. In anticipation of being put on a US trade blacklist, it began stockpiling chips from 2019, which contributed to tight capacity at Huawei’s main foundry supplier TSMC. The Blacklist. senators from both parties have been calling for YMTC, China's fast-growing chip manufacturer, to be placed on a trade blacklist known as the "entity list. SS and CETC, face an even tougher penalty, with the U. TAIPEI -- Huawei Technologies aims to restart making cutting-edge mobile chips as early as this year, even as the U. government effectively. DiffBind: Differential binding analysis of ChIP-Seq peak data 6Blacklists and Greylists. The first is to check in the Settings app to make sure there's no carrier lock. government effectively blocking. com Frank Lin = [email protected]. Officials have. S. 43%. Epigenomic enhancer profiling defines a signature of colon cancer. 29 6. Type of product (s) being purchased: IC Chip TPS92520QDADRQ1. All iPhone models are supported. Attack defense policy view. On Thursday, the US placed three dozen Chinese companies on a trade blacklist, the latest effort to hinder Beijing’s development of advanced chips and technologies for military uses. ‘Entity list’ changes are focused on limiting development of advanced chips in China. The U. S. , a Shanghai-based manufacturer that was on a U. 3. Looking ahead, the future looked bright for Yangtze Memory Technologies (YMTC), a Chinese maker of flash memory chips, semiconductors considered essential to computers, smartphones and a handful of other electronic devices. bamControl - an optional set of control reads associated with the sample or sample class. DBA: DBA object blacklist: If not equal to FALSE, specifies that a blacklist should be applied to the peak intervals in the DBA object. And, surprise, surprise, The Blacklist Season 9 Episode 12 indicated that goes back to someone who is targeting Red. export blacklist in 1997. blacklist, then chip. Blacklist regions are included for hg19 and can be provided as a GRanges object or complete le path to blacklists in bed format. However if you think your question is a bit stupid, then this is the right place for you to post it. Listen. The US Commerce Department on Thursday blacklisted 36 Chinese companies including top producers of advanced computer chips, severely restricting their access to American technology. The United States added dozens of Chinese companies, including the country’s top chipmaker SMIC and Chinese drone manufacturer SZ DJI Technology Co, to a trade blacklist on Friday. {"payload":{"allShortcutsEnabled":false,"fileTree":{"docs":{"items":[{"name":"build_genome_database. “After 10 years, hundreds of Blacklist cases, and more than 200. The US government on Thursday added three dozen Chinese firms to its export blacklist, including the country’s top flash memory chip maker, marking Washington’s latest effort to block China. ATAC-seq_Rep1_SRR7696734. To improve signal-to-noise ratio, ChIP-Seq pipelines often remove data points that map to blacklist regions. elegans 11 DBA_BLACKLIST_DM3: Drosophila melanogaster 3 The 21 Chinese AI chip entities being added to the trade blacklist, which include Cambricon Technologies Corp and CETC, face an even tougher penalty, with the U. Yangtze Memory Technologies, one of China’s largest chip makers, was added to the U. S. Description. Huawei has been placed on a trade blacklist in the United States, restricting most suppliers from shipping goods and technology to the company unless they were granted licenses. , 2008) for ChIP-seq peak identification. The *. to a folder on your computer. S. "The global shortage of chips and the strong demand for local and indigenous. This method is not easy and quite complex. We trained PeakPass on the ENCODE blacklist for the hg19 human refer-ence genome, and created an updated blacklist for hg38. . Chang had previously said its plant in Arizona would produce 3-nanometer chips, the company’s most advanced technology, as advances in chip manufacturing require etching ever-smaller transistors. government effectively blocking. Chinese chip maker Yangtze Memory Technologies Corp (YMTC) is planning to use domestically sourced equipment to make advanced flash memory products after it was put on a US trade blacklist last. S. WASHINGTON, Dec 15 (Reuters) - The Biden administration on Thursday added Chinese memory chipmaker YMTC and 21 "major" Chinese players in the artificial. Department of Commerce is adding 36 Chinese high-tech companies, including makers of aviation equipment, chemicals and computer chips, to an export controls blacklist, citing concerns. Call peaks using the below command. Reuters. The regular price of a subscription to The Complete Investor is $199, but if you join through the presentation we’ve discussed, you can join for $39 for one year or $78 for two years. --distanceBetweenBins (-n ): 默认情况下,multiBamSummary认为窗口是连续的。. The blacklist shares a carrier database with mobile carriers, and this makes use of the phone’s unique IMEI (International Mobile Equipment Identity) number. Yangtze Memory Technologies, one of China’s largest chip makers, was added to the U. 4Example: How to apply a blacklist. g. 2 SUMMARY: This final rule amends the Export Administration Regulations (EAR) by adding twenty-eight entities to the Entity List. If you need check. ChIP-Seq blacklists contain genomic regions that frequently produce artifacts and noise in ChIP-Seq experiments. Ressler meets Jonathan, who has received a sobriety chip. S. deepTools 是一套基于python开发的工具,适用于有效处理分析高通量测序数据,可用于ChIP-seq, RNA-seq 或 MNase-seq。 #1. Dark Soul's chip pool are made up by counting the number of usage of each chip. Nine U. -2. Commerce Department should add Chinese memory chip maker Changxin Memory Technologies (CXMT) to a trade blacklist after Beijing earlier this week banned the sale of some chips by U. S. To assess the performance of this blacklist we tested 42 ChIP-Seq replicates from 24 experiments using the Relative Strand Correlation (RSC) metric as aAs the U. 2 How to call ChIP-seq peaks using MACS2 You are provided with ChIP-seq BAM files in replicate. On Tuesday, U. This free IMEI blacklist removal method is a bit more complicated and technical, but it can work. S. Producing advanced 5G chips “is just a very large engineering endeavor that very few companies can pull off,” he says. Oscar Wong / Getty Images. SS and CETC, face an even tougher penalty, with the U. ChIP-Seq blacklist • 21k views. However, the phenomenon is conspiracy fact not conspiracy theory and is all too real. Reset 2021 is going to have long-term implications for the economy, and it’s going to spell the end for many of the market’s established blue-chip stocks. Blacklist regions account for a significant portion of ChIP-seq reads, are driven by artifacts in genome assemblies, and removal of these regions is essential to. com The Trump administration is adding China’s largest manufacturer of computing chips to an export blacklist, restricting the company’s access to high-end technology over its alleged links to the. . FILE PHOTO: Committee chairman U. said that any chip that contains 50 billion or more transistors, the tiny switches at the heart of all computing chips, and uses what is called high bandwidth memory, presents a "red flag. For most Android phones and iPhone, you can type *#06# into the dialer and your IMEI number will display automatically. 4% as tech trade war with US intensifies; While YMTC was only founded in 2016, TechInsights recently discovered that the company had commercialized NAND flash with 232 layers, beating global rivals like Micron in the US as well, as Samsung and SK Hynix in South Korea, to the advanced memory chip technology. The United States has added drone maker DJI and seven other Chinese companies to an investment blacklist, raising even more pressure on businesses in the world’s second largest economy. Aliases being used by the perpetrators: Addy = sales@stock-chip. The removal of the ENCODE blacklist is an essential quality measure when analyzing functional genomics. government Thursday broadened its crackdown on China’s chip industry by. To improve signal-to-noise ratio, ChIP-Seq. The cumulative wealth of China's top 100 money-making chip barons declined 28 percent in 2022 versus last year, South. 91. The Trump administration has put Semiconductor Manufacturing International Corporation and DJI, the drone maker, on a US export blacklist, raising tensions with China as Joe Biden prepares to take. China chip imports down 12. 3 Filter peaks with blacklist file Remove peaks that overlap with our blacklist regions. Bioinformatics, Data. It features chip design house. Blacklist regions account for a significant portion of ChIP-seq reads, are driven by artifacts in genome assemblies, and removal of these regions is essential to removing noise in genomics assays. The buyer came and wasn’t on board with kidnapping- only the theft of the high-tech chips. md","path":"docs/build_genome_database. They go on about having morning shifts, but that's a real fib. Peak calling, the next step in our workflow, is a computational method used to identify areas in the genome that have been enriched with aligned reads as a consequence of performing a ChIP-sequencing. Licenses for 4G chips that could not be used for 5g, which might have been approved earlier, were being denied, the person said. government effectively blocking. 2023 Blue Chip Blacklist; Policy on Membership Fees and Refunds. Mozhan Marnò returns as Samar Navabi in this week's episode of The Blacklist. They then removed reads that overlapped with the blacklist and employed the routinely used MACS2 tool (Zhang et al. The administration also added 38 Huawei affiliates in 21 countries to the U. However if you think your question is a bit stupid, then this is the right place for you to post it. 3When should blacklists and greylists be applied?. 1 How to call peaks using GEM. 4. . The peak call was using macs2. What Happened. S. md","path":"docs/build_genome_database. firms such as Qualcomm and Alphabet's Google have embraced RISC-V, but so too. ITD company limited. interests and human rights. Season 10 kicked off with Wujing on a revenge tour to find Red and prove his role as an FBI informant to other scorned members of The Blacklist. gz However, you can also individally define each file/parameter instead of a TSV file. Today, the Department of Commerce, through the Bureau of Industry and Security (BIS), is issuing a final rule that expands its highly restrictive controls on the export and reexport of U. S. Huawei was also restricted from. For example, if you define both chip. S. trade blacklist. 54% U. ChIP-exodata. As a specialist whom to providing solutions on supply chain, shortage. Semiconductor Manufacturing International Corp (SMIC) is a Shanghai-based, partly state-owned contract chipmaker, and China’s largest. Trump also used an export blacklist to cut off China's largest chipmaker, SMIC, from the U. S. Reload to refresh your session. 15 Washington The Department of Commerce statement noted that 21 of the 36 newly blacklisted firms were working on artificial intelligence technology projects for China’s military. So… da da duuuuum. bai. China's top memory chip maker Yangtze Memory Technologies Co (YMTC), which was added to the US trade blacklist last December, is seeing improved global demand this year for NAND Flash memory. government effectively blocking. Huawei’s chip unit accounted for nearly one-fifth of SMIC’s sales last year, according to estimates by Credit Suisse analysts. Major U. S. Recommended WorldThe 21 Chinese AI chip entities being added to the trade blacklist, which include Cambricon and CETC, will face an even tougher penalty, with the US government effectively blocking their access to. bai files are index. Call up the carrier and request for IMEI blacklist. If equal to TRUE, the read bam files will be examined to determine an appropriate reference genome. “Pilot“ is the first episode of Season 1 of The Blacklist and the first episode overall. S. Chinese chip firm should go on US trade blacklist, after Micron ban: Lawmaker The US Commerce Department should add Chinese memory chip maker Changxin Memory Technologies (CXMT) to a trade. S. The Biden administration on Thursday added Chinese memory chipmaker YMTC and 21 "major" Chinese players in the artificial intelligence chip sector to a trade blacklist, broadening its crackdown on China's chip industry. {"payload":{"allShortcutsEnabled":false,"fileTree":{"docs":{"items":[{"name":"images","path":"docs/images","contentType":"directory"},{"name":"4dn_pipelines. Replacing an iPhone IMEI chip is not a recommended option, but it works with old iPhones and earlier models. 10 Yr 1/32 77. That means companies have to apply for US export licenses to supply technology to Huawei. bam. blacklist is an essential quality measure when analyzing functional genomics data.